Myoblasts Fuse When Loner Meets ARF6

Myoblasts fuse when loner meets ARF6.

Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players.

Control of Myoblast Fusion by a Guanine Nucleotide Exchange Factor, Loner, and Its Effector ARF6

Myoblast fusion is essential for the formation and regeneration of skeletal muscle. In a genetic screen for regulators of muscle development in Drosophila, we discovered a gene encoding a guanine nucleotide exchange factor, called loner, which is required for myoblast fusion. Loner localizes to subcellular sites of fusion and acts downstream of cell surface fusion receptors by recruiting the sm...

When to Fuse Two Biometrics

Biometric fusion, acquisition and combination of multiple pieces of evidence of identity, can achieve higher accuracy of biometric recognition than using a single biometric. However, fusion increases the cost or throughput of the system since it requires acquisition and processing of more samples. We document a procedure for contingent fusion. That is, two biometrics are fused only if verificat...

When Science Meets Religion

When Turing Meets Milner

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